Presentation of Bioorganic Chemistry and Biomaterials Research Group and its Results in the Adaptive Synthesis of Dendritic Structures and their Specific Properties

In the Research Group of Bioorganic Chemistry and Biomaterials, we are investigating glycomimetics and nanomolecular dendritic carriers such as (glyco)dendrimers, dendrons, and amphiphilic molecules. Glycomimetics are synthetic analogs of bioactive carbohydrates. Alone or bound to dendritic carriers, they allow us to study, modulate, stimulate, or inhibit some biomedically important processes, especially those mediated by the glycocalyx, a very dense network of oligosaccharides bound to proteins and lipids on the cell surface. Dendrons and dendrimers are promising carriers of drugs, nucleic acids, peptides, and other active species in biomedicine. Our group has developed an adaptive synthesis providing dendritic structures in high yields. This synthesis has been used to prepare several series of dendrons exhibiting, for example, the formation of highly stable supramolecular objects, antimicrobial effects surpassing some common antibiotics, or the ability to enter the cell cytosol and serve as probes for confocal fluorescence microscopy.