Abstract:
Although enantiomers exhibit identical chemical and physical properties in the achiral environment, their biochemical and pharmacological properties may vary, leading to differences in their therapeutic effect as well as side effects. The preparation of optically pure compounds, especially pharmaceuticals, is, therefore, a challenge. One of the possible effective and scalable ways to ensure optical purity is the chiral separation of racemic mixtures by chiral membranes. Chiral membranes can form a barrier between the racemic mixture solution and the pure solvent and ensure the preferential transport of one enantiomer of the target substance. The main objective of this project is the design and synthesis of new chiral membranes using a unique modular approach supported by molecular dynamic modeling, which will allow effective optimization of chiral recognition of the target membrane, which will lead to a high-efficiency distribution of enantiomers of a racemic mixture of choice.