Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions

We have designed the reversible biphasic system for practical use in asymmetric hydrogenation performed in a microfluidic chip reactor. Methyl acetoacetate (MAA) was transformed to (R)-methyl hydroxybutyrate over optically pure (R)-Ru-BINAP catalyst as a model reaction. The reaction mixture is homogenous under reaction conditions while after the cooling two phases are formed. The methanolic phase contains the desired product, while the ionic liquid phase contains the ionic liquid with (R)-Ru-BINAP catalyst that can be simply reused in the reaction.

• Klusoň P., Stavárek P., Pěnkavová V., Vychodilová H., Hejda S., Bendová M., Došek M., Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions. Chem. Eng. Res. Des. 153, 537-546, 2020. DOI