Preparation of new helicene derivatives

The synthetic approach leading to helicenes is based on a patented photooxidative cyclization of stilbene precursors. By transferring the synthesis to a flow system, we are capable of preparing helicenes on a multigram scale, which is sufficient not only for studying their properties and applications but also for further chemical transformations. Helicenes usually undergo reactions that are typical for simpler aromatics; their reactivity, however, is non-trivial, and thorough optimization is often required even for otherwise simple reactions. Nevertheless, it is often possible to introduce reactive functionalities either before the cyclization or in the later stages. This leads to the preparation of versatile materials with enormous application potential. Some helicene derivatives exhibit intrinsic photochemistry, which can be easily exploited for otherwise forbidden transformations.

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