Chiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications
Research Group of Advanced Materials and Organic Synthesis (GAMOS) has been actively engaged in the synthesis and study of chiral [n]helicenes, which exhibit a helical (spiral) geometry. While helicene chemistry has traditionally been associated with materials science, their unique chiroptical properties have attracted increasing interest in other fields, particularly biomedicine. Helical symmetry is widespread in nature and can be found in living organisms, for example, in the structure of DNA and the spatial arrangement of certain proteins. This distinctive structural organization enables new applications of enantiomerically pure helicenes in biochemistry and biotechnologies, particularly through selective interactions with biomolecules. Additionally, helicenes hold significant potential in sensing and detection, as well as in medicinal chemistry and therapeutic applications.
A recently published review in the prestigious journal Biotechnology Advances (Elsevier) focuses on helicenes and “helicene-like” structures, summarizing their extensive biomedical applications. The review highlights their roles in cell imaging, targeted drug delivery, biosensing, and developing novel pharmaceuticals. It also discusses the specific interactions between helicenes and biomolecules and their potential in therapeutic applications. Furthermore, the review explores recent advances in helicene derivatives with enhanced photochemical properties, which expand their use in bioimaging and diagnostics. This study consolidates current knowledge in these interdisciplinary fields and underscores the importance of helicenes at the intersection of materials science, chemistry, physics, and biology. It aims to inspire further research of these unique molecules in innovative technological and biomedical applications.
- Bouz G.*, Žádný J., Storch J., Vacek J.: Chiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications. Biotechnol. Adv. 2025, 79(1 March), 108513. doi.org/10.1016/j.biotechadv.2024.108513